As Evelyn said, make sure it is hormones. I felt like the poster child for messed up hormones. Gained 100 lbs after a total hysterectomy and didn't take HRT's. Finally put two and two together and saw many doctors.
I began by doing a saliva test which I got online and sent for evaluation. They were crazy. Totally out of whack. They claimed PCOS, but I'd already had a hysterectomy with ovaries removed. After a year of fruitlessly popping vitamins (45/daily) prescribed by a self-proclaimed hormone specialist, I gave up on her and knew I had to find someone who really understood hormones.
Took 20 years, but I found a GYN who specialized in hormone inbalances. She then referred me to an Endocrinologist who believed in treating a patient according to symptoms and not lab values dating back to 1972. I'm on Armour Thyroid 60mg.
High estrogens will hold you back from losing weight.
My current doc has me on "troches" which are compounded. Bioidentical hormones with estrogen at 1.25 to 50 Progesterone. Took a year, but I found the perfect balance.
Just beware of the places that advertise "fatigue, sexual dysfunctions, etc". It's a high priced business where they sometimes implant hormones under the skin.